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高惠陽

OFFICE: Department of Ophthalmology                                                                    Tel# (513) 558-2802
               College of Medicine University of Cincinnati                                                Fax # (513) 558-3108
               3223 Eden Avenue, M.L. 527
               Cincinnati, OH 45267-0527
E-mail:   Winston.Kao@UC.Edu
BIRTHPLACE: Tainan, Taiwan MARITAL STATUS: Married - Candace,
CITIZENSHIP: Naturalized U.S. Citizen
EDUCATION:
                      Location Degree Year Major
                      National Taiwan University B.S. 1966 Medical Technology
                      National Taiwan University M.S. 1970 Biochemistry
                      University of Pennsylvania Ph.D. 1974 Biochemistry
                      Rutgers Medical School CMDNJ Postdoctoral 1976 Biochemistry
PROFESSIONAL EXPERIENCE:
                      Sept. 2008-Present Ben and Louis Tate Chair Professor, Ophthalmology
                                                      Director, Crawley Vision Research Center
                                                      Member, All University Graduate Faculty at University of Cincinnati
                      Sept. 2001               Ben and Louis Tate Chair Professor, Ophthalmology
                                                      Director of Ophthalmic and Connective Tissue Research, University of Cincinnati
                                                      Member, All University Graduate Faculty at University of Cincinnati
                      Sept. 1990-2001     Professor of Ophthalmology
                                                      Director of Ophthalmic and Connective Tissue Research, University of Cincinnati
                                                     Member, All University Graduate Faculty at University of Cincinnati
                                                     Mechanism of Corneal Epithelial Cell Differentiation
                                                     Regulation of Extracellular Matrix Metabolism during Wound Healing
                      June 1982-             Associate Professor, Department of Ophthalmology
                      August 1990           Director of Ophthalmic and Connective Tissue Research, Associate Professor in the Department of                                                                      Ophthalmology, Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of                                                                Medicine, Cincinnati, Ohio
                                                     Member, All-University Graduate Faculty at University of Cincinnati,
 1989
                                                     Develop ophthalmic research programs. Major research interests are the regulation of collagen gene                                                                  expression during embryonic development and pathogenesis of ocular and pulmonary tissues.
                      Sept. 1979 -            Assistant Professor, Department of Ophthalmology, University of Pittsburgh
                      June 1982              School of Medicine, Pittsburgh, Pennsylvania.
                                                     Purify and characterize prolyl hydroxylase from L-929 cells, human tissues and other sources. Purify                                                                    mammalian collagenase to investigate the process of wound healing in cornea and immune response in                                                              microbial infections in the cornea. Purify and characterize procollagens and collagens and examine their                                                              synthesis in developing embryos and diseased tissues, and to investigate the mechanism of differentiation                                                          and gene expression in developing chick embryos.
                      1976-1979             Research Assistant Professor, Department of Ophthalmology, University of Pittsburgh School of Medicine,                                                           Pittsburgh, Pennsylvania.
                                                    Same as above.
                      1975-1976             Research/Teaching Specialist III, CMDNJ-Rutgers Medical School, Department of Biochemistry, Piscataway,                                                       New Jersey.
                                                    In charge of the tissue culture laboratory in the department. Investigated collagen biosynthesis in primary                                                             cultures of tendon fibroblasts, cartilage cells, and established cell lines of fibroblasts (L-929). Especially                                                               interested in regulation of secretion of procollagen and metabolism of prolyl 4-hydroxylase. Developing new                                                         technique for quick easy radioimmune assay and general technique for cell cultures.
                      1972-1974             Research Fellow in CMDNJ- Rutgers Medical School, Department of Biochemistry, Piscataway, New Jersey.
                                                    Established laboratory of tissue culture in the department. Investigated the effects of ascorbic acid on the                                                             biosynthesis of procollagen by fibroblasts and on the activity of prolyl hydroxylase.
                      1970-1972             Research Assistant in the Department of Biochemistry School of Medicine, University of Pennsylvania,                                                                 Philadelphia, Pennsylvania.
                                                    Engaged in studies of the transport of sugar in mammalian cells and the methylation of ribosomal RNA in E.                                                         coli.
                      1968-1970             Graduate student in the Department of Biochemistry College of Medicine, National Taiwan University.
                                                    Investigated the effect of plant toxic proteins (such as abrin and ricin) on metabolism of normal and tumor                                                           cells.
                                                    1967-1968 Teaching Assistant, Department of Medical Technology College of Medicine, National Taiwan                                                             University.
AWARDS:

                     RPB - Robert E. McCormick Scholar (1986-1987).
                     RPB’s Senior Scientific Investigator (2003)
                     Visiting Professor
                     Chang Gung Medical College (March, 1993)
                     National Taiwan University (November, 98-March,31, 99)
                     University of Miami (April 1, -May 31, 1999)
PROFESSIONAL SOCIETIES:
                     Member, American Society of Biochemistry and Molecular Biology, 1982 - present
                     Member, Chinese Biochemistry Society, 1972 - present
                     Member, The Association for Research in Vision and Ophthalmology, 1976 - present
                     Member, American Association of Advanced Science, 1982 - present
                     Member, American Society of Cell Biology, 1996 - present
                     Member, International Society of Eye Research, 1987 - present

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